Table 11.
Major genes targeted by miR-330-3p in various types of cancer
| Cancers | Targeted gene products† | References |
|---|---|---|
| Cancers with down-regulation of miR-330-3p | ||
| Acting as oncogenes or tumor promoters | ||
| CRC | TYMS, HK2 | Xu et al. (2017); Gao et al. (2021a) |
| GC | MSI1, PRRX1 | Guan et al. (2016); Ma et al. (2020) |
| LSCC | SLC7A11, TRA2B | Fan and Zhu (2022); Cheng et al. (2020a) |
| OSCC | GLS | Qian et al. (2021) |
| BRCA | MYC | He et al. (2020) |
| PCa | BMI1, E2F1 | Li et al. (2020b); Lee et al. (2009) |
| Acting both as oncogenes and tumor suppressors, or unclassified) | ||
| CRC | MYO6, PFN1 | Wang et al. (2022b); Huang et al. (2020b) |
| NSCLC | GRIA3 | Wei et al. (2019b) |
| OVCA | RIPK4 | Cai et al. (2021) |
| Cancers with up-regulation of miR-330-3p | ||
| Acting as tumor suppressors | ||
| ESCC | PDCD4 | Meng et al. (2015) |
| NSCLC | EGR2, PTEN, RASSF1A | Liu et al. (2015); Wang et al. (2021e); Chen et al. (2019b) |
| BRCA | PDCD4 | Ji et al. (2021) |
| HCC | BTG1, ING4 | Zhao et al. (2019b); Hu et al. (2017a) |
†mRNAs encoding the following proteins: BMI1 encodes BMI1 Proto-Oncogene, Polycomb Ring Finger; BTG1 is a tumor suppressor gene that codes for BTG Anti-Proliferation Factor 1; EGR2 is a tumor suppressor gene that codes for transcription factor Early Growth Response 2; GLS encodes GLS1 (Glutaminase) which promotes proliferation as opposed to proliferation-inhibiting GLS2 (Kim and Kim 2013); GRIA3 encodes Glutamate Ionotropic Receptor AMPA Type Subunit 3; HK2 encodes Hexokinase 2 catalyzing the rate-limiting step of glucose metabolism and is highly expressed in rapidly growing cancer cells; ING4 encodes tumor suppressor protein that can bind p53; MSI1 encodes Musashi RNA-binding protein that is involved in tumorigenesis; MYC encodes transcription factor MYC Proto-Oncogene (c-Myc); MYO6 encodes motor protein Myosin VI; PFN1 encodes Profilin 1 that binds actin monomers and mediates actin polymerization but also inhibit formation of IP3 from PIP2; PDCD4 encodes programmed cell death protein 4 acting as a tumor suppressor; PRRX1 codes for Paired Related Homeobox 1 protein that can promote the EMT process in cancer cells (Du et al. 2021); RASSF1A is a tumor suppressor gene encoding Ras Association Domain Family Member 1; RIPK4 encodes Receptor Interacting Serine/Threonine Kinase 4 and acts as a tumor suppressor or promoter depending on the type of cancer (Xu et al. 2020c); SLC7A11 encodes Cystine/Glutamate Transporter (Koppula et al. 2021); TRA2B is an oncogene encoding Transformer 2 β Homolog