Table 13.
Major genes targeted by miR-375-3p in various types of cancer
| Cancers | Targeted gene products† | References |
|---|---|---|
| Cancers with down-regulation of miR-375-3p | ||
| Acting as oncogenes or tumor promoters | ||
| CRC | TYMS, CBX3, FOXM1, | Xu et al. (2020b); Liu et al. (2020a); Chen et al. (2020b); |
| FZD8, PIK3CA, YAP1 | Xu et al. (2016a); Wang et al. (2014b Xu et al. (2019a | |
| ESCC | MTDH | Hu et al. (2017b) |
| GC | PDPK1, TEAD4, YAP1, | Chen et al. (2017d); Kang et al. (2018) |
| YBX1, YWHAZ | Huang et al. (2019b); Liu et al. (2019b) | |
| OSCC | SLC7A11 | Wu et al. (2017) |
| NSCLC | SPIN1 | Jin et al. (2021) |
| HCC | ERBB2, HMGA2, JAK2 | Li et al. (2018b); Xu et al. (2021); Li et al. (2021b) |
| HCC | MTDH, PDGFC, YAP1 | He et al. (2012); Li et al. (2021c); Liu et al. (2010) |
| HCC CSCs | YAP1 | Zhao et al. (2020a) |
| PDAC | PDPK1, ZFP36L2 | Zhou et al. (2014b); Song et al. (2013a); Yonemori et al. (2017) |
| OVCA | YAP1 | Shu et al. (2021) |
| Acting both as oncogenes and tumor suppressors, or unclassified | ||
| CRC | KLF4, SP1 | Mao et al. (2016); Xu et al. (2019a) |
| GC | CCN2 | Kang et al. (2018) |
| ESCC | HMGB1, IGF1R, SESN3, | Cheng et al. (2020b); Kong et al. (2012); Li et al. (2021a) |
| SP1 | Xu et al. (2019b) | |
| LSCC | HNF1B, IGF1R | Chang et al. (2020); Luo et al. (2014) |
| OSCC | KLF5, IGF1R, PAX6 | Shi et al. (2015); Zhang et al. (2017); Tong et al. (2021) |
| CeCa | SP1 | Wang et al. (2011) |
| Cancers with up-regulation of miR-375-3p | ||
| Acting as tumor suppressors | ||
| BRCA | FOXO1 | Guan et al. (2021) |
| CeCa | CDH1 | Shen et al. (2014) |
| Acting both as oncogenes and tumor suppressors, or unclassified | ||
| PDAC | HOXB3 | Yang et al. (2016) |
†mRNAs encoding the following proteins: CBX3 codes for protein involved in transcriptional silencing (upregulated in cancers); CCN2 codes for connective tissue growth factor; CDH1 is a tumor suppressor gene encoding E-cadherin; ERBB2 codes for HER-2 Receptor Tyrosine Kinase; FOXO1 is a tumor suppressor gene; FZD8 encodes Frizzled Class Receptor 8 which is a receptor for Wnt proteins (Sun et al. (2021); HMGA2 encodes HMG AT-Hook Protein 2, which functions in the regulation of the cell cycle; HMGB1 encodes HMG Box 1, which has both oncogenic and tumor suppression functions; HNF1B encodes Hepatocyte Nuclear Factor 1-β and functions as a tumor suppressor gene or oncogene (Chandra et al. (2021); HOXB3 encodes transcription factor Homeobox B3 (Li et al. (2019b); JAK2 encodes Janus Kinase 2 phosphorylating a tyrosine residue; KLF4 is a tumor suppressor gene encoding Kruppel Like Factor 4, but may also act as an oncogene depending on the cellular context; KLF5 encodes Kruppel Like Factor 5 and acts as an oncogene or tumor suppressor gene depending on the cellular context; PAX6 is a tumor suppressor gene encoding transcription factor Paired Box 6; PDGFC codes for Platelet Derived Growth Factor C (promotes angiogenesis); PDPK1 encodes 3-Phosphoinositide-Dependent Protein Kinase-1 (Domrachev et al. (2021); PIK3CA is an oncogene encoding PI3K, subunit p110α; SESN3 encodes sestrin3, stress-induced protein; SP1 encodes Sp1 Transcription Factor that regulates oncogenes and tumor suppressor genes; SPIN1 encodes Spindlin 1 and is considered an oncogene (Janecki et al. (2018); TEAD4 is an oncogene encoding TEA Domain Transcription Factor 4 (Hippo pathway); YBX1 is an oncogene encoding Y-Box Binding Protein 1; YAP1 is an oncogene encoding Yes1 Associated Transcriptional Regulator (Hippo pathway); ZFP36L2 is an oncogene encoding ZFP36 Ring Finger Protein Like 2; YWHAZ is functioning as an oncogene and codes for an adapter protein belonging to the 14-3-3 family