Table 3.
Major genes targeted by miR-192-5p and miR-215-5p in various types of cancer
| Cancers | Targeted gene products† | References |
|---|---|---|
| Cancers with down-regulation of miR-192/215-5p | ||
| Acting as oncogenes or tumor promoters | ||
| CRC | TYMS, EIF5A2, EREG, HOXB9 | Boni et al. (2010); Song et al. (2010); Zhao et al. (2020b); Chen et al. (2016) |
| RAB2A, YY1, ZEB2 | Vychytilova et al. (2017); Zheng et al. (2019b); Chen et al. (2017c) | |
| BRCA | AKT1, RAD54B, SOX9 | Yao et al. (2017); Wang et al. (2021i); Gao et al. (2019) |
| NSCLC | TRIM44 | Zou et al. (2019) |
| BLCA | YY1 | Ji et al. (2018) |
| HCC | CDC6, SLC39A6, TRIM25 | Xu et al. (2020a); Lian et al. (2016); Wang et al. (2021h) |
| PCa | NOB1 | Sun et al. (2016) |
| Cancers with up-regulation of miR-192/215-5p | ||
| Acting as tumor suppressors | ||
| GC | RB1, RUNX1 | Chen et al. (2017e); Deng et al. (2014b); Li et al. (2016 |
| ESCC | BCL2L11 | Li et al. (2015c) |
†mRNAs encoding the following proteins: AKT1 encodes AKT Serine/Threonine Kinase 1; BCL2L11 codes for pro-apoptotic BH3-only protein BIM; CDC6 is an oncogene encoding Cell Division Cycle 6 Homolog; EIF5A2 is an oncogene encoding Eukaryotic Translation Initiation Factor 5A2; EREG codes for Epiregulin, ligand of epidermal growth factor receptor (Cheng et al. (2021); HOXB9 encodes transcription factor Homeobox B9 (Contarelli et al. 2020); NOB1 is an oncogene encoding Nin One Binding Protein; RAB2A is an oncogene encoding a member of the RAS family; RAD54B is an oncogene encoding helicase RAD54 Homolog B involved in homologous recombination and DNA repair (Zhang et al. 2019c); RB1 is a tumor suppressor gene encoding RB Transcriptional Corepressor 1, a key regulator of the G1/S transition in the cell cycle; RUNX1 is tumor suppressor gene coding for RUNX Family Transcription Factor 1; SLC39A6 is an oncogene that encodes a zinc-influx transporter; SOX9 is an oncogene encoding SRY-Box Transcription Factor 9; TRIM25 encodes E3 ubiquitin ligase involved in p53 inactivation (Zhang et al. 2015); TRIM44 is an oncogene encoding a protein involved in the ubiquitination and degradation of target proteins; YY1 is an oncogene encoding Yin Yang 1 transcriptional factor; ZEB2 encodes Zinc Finger E-Box Binding Homeobox 2, a transcriptional corepressor promoting the EMT process in cancer cells