Table 4.
Treatment with ZM447439 (ZM) and Barasertib (BS) inhibitors
| DMSO (ZM) | ZM447439 | DMSO (BS) | Barasertib | |
|---|---|---|---|---|
| Aurora B | 0.00 ± 0.00 | 0.00 ± 0.00 | 2.81 ± 1.14 | 10.00 ± 0.00* |
| MKLP1 | 2.34 ± 3.21 | 32.68 ± 0.87*** | 7.50 ± 4.95 | 21.00 ± 4.24*** |
| BAF53a | 5.67 ± 2.08 | 16.00 ± 5.00*** | 6.50 ± 0.71 | 24.50 ± 4.95*** |
| Tip60 | 2.58 ± 1.37 | 42.00 ± 3.00*** | 4.78 ± 1.48 | 30.34 ± 2.50*** |
| SRCAP | 0.34 ± 0.58 | 1.33 ± 2.31 | 0.48 ± 0.67 | 1.43 ± 0.71 |
The results are expressed as mean ± SD values from three independent replicate experiments
Experimental groups were compared with DMSO-treated controls by Fisher's exact test. *=P <0.05; **=P < 0.005; and ***=P < 0.0005