Table 5.
Quantitative analysis of defects found in CRS-depleted S2 cells
| Mock | MRG15 | Tip60 | Yeti | ||
|---|---|---|---|---|---|
| Metaphase | MS | 0.37 ± 0.64 | 34.28 ± 4.39*** | 35.06 ± 1.75*** | 19.94 ± 2.84*** |
| CM | 0 | 12.79 ± 4.03*** | 35.16 ± 3.66*** | 12.81 ± 1.60*** | |
| Telophase | CB | 0 | 3.97 ± 0.55 | 5.08 ± 0.85* | 6.99 ± 4.54** |
| LIB | 0.13 ± 0.22 | 9.02 ± 0.74*** | 1.92 ± 1.76* | 11.54 ± 3.84*** | |
| MC | 0.53 ± 0.29 | 1.98 ± 0.79*** | 1.70 ± 0.80** | 4.14 ± 0.84*** |
MS multipolar spindles, CM chromosome misalignments, CB chromatin bridges, LIB long intercellular bridges, MC multinucleated cells
The results are expressed as mean ± SD values from three independent replicate experiments
Experimental groups were compared with mocks by Fisher's exact test. *=P < 0.05; **=P < 0.005; and ***=P < 0.0005