Table 2.

PICOTS system

PICOTS	Explanation
Population	Target population in which the prognostic model will be used.
Index model	Prognostic model(s) under review.
Comparator model	If applicable (depending on the review question), competing prognostic models for the index model.
Outcome(s)	Outcome(s) of interest that is (are) predicted by the prognostic model(s).
Timing	1. Moment in time the prognostic model is to be used 2. Time period over which the outcome occurrence is predicted by the prognostic model (prediction horizon).
Setting	Intended setting or context of the prognostic model(s) under review.

PICOTS, Population, Index model, Comparator model, Outcome(s), Timing, Setting.