Skip to main content
. 2022 Aug 3;17:51. doi: 10.1186/s13024-022-00556-6

Fig. 1.

Fig. 1

Linear structural features of apoE and the amino acid differences among common and rare variants. The numbers depict amino acid residues of the protein sequence. ApoE has three structural domains: N-terminal domain (1-167), hinge domain (168-205), and C-terminal domain (206-299). The receptor-binding region in the N-terminal domain and the lipid-binding region in the C-terminal domain are marked. ApoE3-Christchurch is abbreviated as ApoE3-Ch whereas ApoE3-Jacksonville is abbreviated as ApoE3-Jac