Table 1.

Susceptibility Genes of HUA and Gout

Classification	Gene name	Gene product	Location (human)	Tissue distribution	Refs
Production	HPRT1	HPRT1	Xq26.2-q26.3	Multi-tissue expression	NCBI, [9]
	PRPS1	PRS1	Xq22.3	Multi-tissue expression	NCBI, [10]
	ALDH16A1	ALDH16A1	19q13.33	High expression in kidney	NCBI, [11]
Reabsorption	SLC22A11	OAT4	11q13.1	Kidney	NCBI, [12, 13]
	SLC22A12	URAT1	11q13.1	Kidney	NCBI, [13]
	SLC22A13	OAT10	3p22.2	Kidney	NCBI, [14]
	SLC2A9	GLUT9	4p16.1	Liver and kidney	NCBI, [15]
Excretion	ABCG2	BCRP	4q22.1	Kidney and other tissues	NCBI, [16]
	ABCC4	MRP4	13q32.1	Kidney and other tissues	NCBI, [17]
	SLC22A6	OAT1	11q12.3	Kidney and other tissues	NCBI, [13, 18]
	SLC22A8	OAT3	11q12.3	Kidney and other tissues	NCBI, [13, 18]
	SLC17A1	NPT1	6p22.2	Kidney and other tissues	NCBI, [12]
	SLC17A3	NPT4	6p22.2	Kidney and other tissues	NCBI, [12, 19]
	SLC17A4	NPT5	6p22.2	Kidney and other tissues	NCBI, [12, 20]
	SLC2A12	GLUT12	6q23.2	Kidney and other tissues	NCBI, [21]
Other	PDZK1	Various scaffold proteins	1q21.1	Liver, kidney and other tissues	NCBI, [22]
	GCKR	GKRP	2p23.3	Liver	NCBI
	PKD2	Polycytin-2	4q22.1	Multi-tissue expression	NCBI, [23, 24]
	SLC16A9	MCT9	10q21.2	Kidneys and other tissues	NCBI, [12]
	CARMIL1	CARMIL1	6p22.2	Kidney and other epithelial tissues	NCBI, [25]
	SCGN	Secretagogin	6p22.2	Neuroendocrine tissue and pancreas	NCBI, [12]
	UMOD	THP	16p12.3	The major secretory protein in urine	NCBI, [26, 27]