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. 2022 Aug 2;8(3):e001291. doi: 10.1136/bmjsem-2021-001291

Table 1.

Mendelian randomisation (MR) results for the putative effect of sedentary behaviour and physical activity on visceral adipose tissue

Exposure Self-report Accelerometer
SNPs (#) Effect 95% CI SNPs (#) Effect 95% CI
Sedentary behaviour
 IVW 128 0.24*** 0.20 to 0.29 4 0.15 −0.01 to 0.31
 MVMR 0.38*** 0.27 to 0.49 0.04 −0.14 to −0.23
 MR-Egger 0.34** 0.13 to 0.56 0.00 −0.69 to 0.69
 Weighted mode 0.24*** 0.13 to 0.36 0.03 −0.17 to 0.24
 Weighted median 0.24*** 0.20 to 0.28 0.07 −0.07 to 0.22
 MR-PRESSO 0.30*** 0.21 to 0.38 0.12 −0.06 to 0.30
 CAUSE 0.23*** 0.19 to 0.28 0.1 −0.01 to 0.21
Moderate PA
 IVW 32 0.08 −0.01 to 0.17
 MVMR 0.14 −0.07 to 0.36
 MR-Egger 0.08 −0.21 to 0.38
 Weighted mode 0.04 −0.13 to 0.21
 Weighted median 0.03 −0.05 to 0.12
 MR-PRESSO 0.13 −0.08 to 0.33
 CAUSE 0.25 0.02 to 0.47
MVPA
 IVW 93 −0.09** −0.14 to −0.03 46 −0.14*** −0.19 to −0.08
 MVMR 0.05 −0.09 to 0.19 −0.12** −0.19 to −0.04
 MR-Egger −0.18 −0.4 to 0.03 −0.09 −0.24 to 0.06
 Weighted mode −0.04 −0.17 to 0.09 −0.03 −0.18 to 0.11
 Weighted median −0.07 −0.12 to −0.01 −0.09** −0.16 to −0.03
 MR-PRESSO −0.08 −0.21 to 0.05 0.00 −0.03 to 0.03
 CAUSE −0.06 −0.16 to 0.04 −0.11*** −0.15 to −0.07
Vigorous PA
 IVW 61 −0.31*** −0.31 to −0.13 26 −0.19*** −0.25 to −0.13
 MVMR −0.02 −0.34 to 0.29 −0.15*** −0.24 to −0.07
 MR-Egger 0.05 −0.2 to 0.3 −0.24 −0.51 to 0.02
 Weighted mode −0.09 −0.34 to 0.15 −0.23 −0.39 to −0.06
 Weighted median −0.14** −0.24 to −0.04 −0.19*** −0.28 to −0.1
 MR-PRESSO −0.12 −0.40 to 0.16 −0.09 −0.16 to −0.02
 CAUSE −0.13 −0.33 to 0.06 −0.14*** −0.19 to −0.08
SSOE*/overall PA†
 IVW 98 −0.37*** −0.47 to −0.27 6 −0.28 −0.49 to −0.06
 MVMR −0.27 −0.52 to −0.01 −0.21 −0.44 to 0.02
 MR-Egger −0.09 −0.45 to 0.26 −0.25 −1.08 to 0.57
 Weighted mode −0.37 −0.73 to 0.0 −0.17 −0.39 to 0.06
 Weighted median −0.31*** −0.41 to −0.21 −0.21 −0.38 to −0.03
 MR-PRESSO −0.33** −0.55 to −0.11 −0.05 −0.16 to 0.05
 CAUSE −0.28 −0.46 to −0.11 −0.08 −0.19 to 0.03

***P<0.001, **p<0.01.

*Analyses only conducted for self-report PA.

†Analyses only conducted for accelerometer-measured PA.

CAUSE, causal analysis using summary effect; IVW, inverse variance weighted; MVMR, multivariable MR; MVPA, moderate-to-vigorous PA; PA, physical activity; PRESSO, pleiotropy residual sum and outlier; SNPs, single nucleotide polymorphisms; SSOE, strenuous sports and other exercises.