Table 1.
Exposure | Self-report | Accelerometer | ||||
SNPs (#) | Effect | 95% CI | SNPs (#) | Effect | 95% CI | |
Sedentary behaviour | ||||||
IVW | 128 | 0.24*** | 0.20 to 0.29 | 4 | 0.15 | −0.01 to 0.31 |
MVMR | 0.38*** | 0.27 to 0.49 | 0.04 | −0.14 to −0.23 | ||
MR-Egger | 0.34** | 0.13 to 0.56 | 0.00 | −0.69 to 0.69 | ||
Weighted mode | 0.24*** | 0.13 to 0.36 | 0.03 | −0.17 to 0.24 | ||
Weighted median | 0.24*** | 0.20 to 0.28 | 0.07 | −0.07 to 0.22 | ||
MR-PRESSO | 0.30*** | 0.21 to 0.38 | 0.12 | −0.06 to 0.30 | ||
CAUSE | 0.23*** | 0.19 to 0.28 | 0.1 | −0.01 to 0.21 | ||
Moderate PA | ||||||
IVW | 32 | 0.08 | −0.01 to 0.17 | — | ||
MVMR | 0.14 | −0.07 to 0.36 | — | |||
MR-Egger | 0.08 | −0.21 to 0.38 | — | |||
Weighted mode | 0.04 | −0.13 to 0.21 | — | |||
Weighted median | 0.03 | −0.05 to 0.12 | — | |||
MR-PRESSO | 0.13 | −0.08 to 0.33 | — | |||
CAUSE | 0.25 | 0.02 to 0.47 | — | |||
MVPA | ||||||
IVW | 93 | −0.09** | −0.14 to −0.03 | 46 | −0.14*** | −0.19 to −0.08 |
MVMR | 0.05 | −0.09 to 0.19 | −0.12** | −0.19 to −0.04 | ||
MR-Egger | −0.18 | −0.4 to 0.03 | −0.09 | −0.24 to 0.06 | ||
Weighted mode | −0.04 | −0.17 to 0.09 | −0.03 | −0.18 to 0.11 | ||
Weighted median | −0.07 | −0.12 to −0.01 | −0.09** | −0.16 to −0.03 | ||
MR-PRESSO | −0.08 | −0.21 to 0.05 | 0.00 | −0.03 to 0.03 | ||
CAUSE | −0.06 | −0.16 to 0.04 | −0.11*** | −0.15 to −0.07 | ||
Vigorous PA | ||||||
IVW | 61 | −0.31*** | −0.31 to −0.13 | 26 | −0.19*** | −0.25 to −0.13 |
MVMR | −0.02 | −0.34 to 0.29 | −0.15*** | −0.24 to −0.07 | ||
MR-Egger | 0.05 | −0.2 to 0.3 | −0.24 | −0.51 to 0.02 | ||
Weighted mode | −0.09 | −0.34 to 0.15 | −0.23 | −0.39 to −0.06 | ||
Weighted median | −0.14** | −0.24 to −0.04 | −0.19*** | −0.28 to −0.1 | ||
MR-PRESSO | −0.12 | −0.40 to 0.16 | −0.09 | −0.16 to −0.02 | ||
CAUSE | −0.13 | −0.33 to 0.06 | −0.14*** | −0.19 to −0.08 | ||
SSOE*/overall PA† | ||||||
IVW | 98 | −0.37*** | −0.47 to −0.27 | 6 | −0.28 | −0.49 to −0.06 |
MVMR | −0.27 | −0.52 to −0.01 | −0.21 | −0.44 to 0.02 | ||
MR-Egger | −0.09 | −0.45 to 0.26 | −0.25 | −1.08 to 0.57 | ||
Weighted mode | −0.37 | −0.73 to 0.0 | −0.17 | −0.39 to 0.06 | ||
Weighted median | −0.31*** | −0.41 to −0.21 | −0.21 | −0.38 to −0.03 | ||
MR-PRESSO | −0.33** | −0.55 to −0.11 | −0.05 | −0.16 to 0.05 | ||
CAUSE | −0.28 | −0.46 to −0.11 | −0.08 | −0.19 to 0.03 |
***P<0.001, **p<0.01.
*Analyses only conducted for self-report PA.
†Analyses only conducted for accelerometer-measured PA.
CAUSE, causal analysis using summary effect; IVW, inverse variance weighted; MVMR, multivariable MR; MVPA, moderate-to-vigorous PA; PA, physical activity; PRESSO, pleiotropy residual sum and outlier; SNPs, single nucleotide polymorphisms; SSOE, strenuous sports and other exercises.