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METTL3 regulates RPE inflammation by NR2F1 in an m6A-dependent manner. In normal RPE cell, METTL3 methylates NR2F1 and then decreases protein level of NR2F1, which lead to reduced IL-6 transcription and secretion but increased Occludin expression (Left). In METTL3-silenced RPE cell, NR2F1 is increased and then promotes IL-6 secretion but inhibits Occludin expression, which finally lead to increased inflammation (Right).
