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. 2022 Jul 25;119(31):e2204114119. doi: 10.1073/pnas.2204114119

Fig. 3.

Fig. 3.

H-20 inhibits neuronal hyperexcitability and neuropathic pain after nerve injury. (A–D) H-20 attenuated the SNI-induced mouse DRGs neuronal hyperexcitability. *P < 0.05, versus SNI group. Twelve neurons per group. (A) Traces of AP of SNI mice DRGs from 2 wk after surgery and the effects of H-20 (300 μM). (B) Rheobase. One-way ANOVA. (C) Frequency of AP. Two-way RM ANOVA. (D) RMP. One-way ANOVA. (E) Intrathecal H-20 (30 nmol) inhibits SNI-induced mechanical allodynia. Mean ± SEM 8 mice per group. *P < 0.05, versus saline group. n.s., no significance. Two-way RM ANOVA.