Table 1.

List of 10 UK Biobank diseases analyzed

Diseases	British ${\mathit{h}}_{\mathit{g}}^2$	British N	British K	Non-B. Eur. N	Non-B. Eur. K	S.A. N	S.A. K	Afr. N	Afr. K
Lung cancer	0.096	408,903	0.006	41,842	0.006	7,048	0.002	7,087	0.003
Bowel cancer	0.160	408,903	0.013	41,842	0.011	7,048	0.005	7,087	0.009
Stroke	0.090	408,903	0.024	41,842	0.020	7,048	0.025	7,087	0.025
COPD	0.172	408,903	0.035	41,842	0.035	7,048	0.022	7,087	0.013
Prostate cancer	0.296	187,889	0.038	18,192	0.032	3,811	0.014	3,096	0.050
T2D	0.372	407,565	0.042	41,642	0.040	6,881	0.155	6,961	0.098
Breast cancer	0.204	221,014	0.061	23,650	0.061	3,237	0.036	3,991	0.028
Depression	0.116	408,903	0.073	41,842	0.075	7,048	0.054	7,087	0.044
CAD	0.206	408,903	0.085	41,842	0.077	7,048	0.140	7,087	0.063
HTN	0.311	408,903	0.323	41,842	0.293	7,048	0.377	7,087	0.425

For each disease, we report the SNP-heritability ($h_g^2$) in UK Biobank British training data and the number of samples (N) and disease prevalence (K) in each UK Biobank training (British) and target (Non-British European, South Asian, or African) population. We note that the sample size and prevalence in British training data includes information from related individuals, but SNP-heritability was estimated using unrelated British individuals. Diseases are listed in order of disease prevalence in British training data. Our primary focus was on 3 well-powered diseases (type 2 diabetes, depression, and hypertension; denoted in bold) with (liability-scale) prediction R² > 0.05 for PRS and/or FH in each target population (no additional criteria were applied).

Non-B. Eur., Non-British European; S.A., South Asian; Afr., African; COPD, chronic obstructive pulmonary disease, defined as chronic bronchitis/emphysema; T2D, type 2 diabetes; CAD, coronary artery disease; HTN, hypertension.