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. 2022 Jul 21;27(14):4664. doi: 10.3390/molecules27144664

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pathway enrichment and pharmaco-connectivity analysis of the DEP signature. (a) Signaling pathway impact analysis (SPIA) of the DEP signature. Green nodes represent pathways that are activated (topology score > 0), and red nodes represent pathways that are inhibited (topology score < 0). (b) Significant positively connected perturbagens to the DEP signature, ranked by lowest p-value and highest Z-score. (c) Pharmaco-connectivity analysis between the positively connected perturbagens and the predicted targets of Galangin based on structural similarity.