Table 1.
Demographic Characteristics of HSCT Recipients with Moderate Risk TA-TMA (N = 48)
| Variable | Value |
|---|---|
| Male sex, n (%) | 23 (47.9) |
| Age at transplantation, yr, median (IQR) | 7.3 (3.4–13) |
| Race, n (%) | |
| Caucasian | 40 (85.1) |
| African American | 6 (12.8) |
| Asian | 0 (0) |
| Mixed | 1 (2.1) |
| Diagnostic group, n (%) | |
| Malignancy | 16 (33.3) |
| Immune deficiency | 10 (20.8) |
| Marrow failure | 13 (27.1) |
| Benign hematology | 6 (12.5) |
| Genetic/metabolic | 3 (6.2) |
| Stem cell donor type, n (%) | |
| Related (MRD, MMRD) | 13 (27.1) |
| Unrelated (MUD, MMUD) | 30 (62.5) |
| Autologous | 5 (10.4) |
| Stem cell source, n (%) | |
| Bone marrow | 31 (64.6) |
| Peripheral blood | 15 (31.2) |
| Cord blood | 2 (4.2) |
| HLA match (allogeneic-HSCT only), n (%) | |
| Fully matched (MRD, MUD) | 28 (65.1) |
| Mismatched (MMR, MMUD, haploidentical) | 15 (34.9) |
| Conditioning regimen type, n (%) | |
| Myeloablative | 30 (62.5) |
| Reduced intensity | 18 (37.5) |
| GVHD prophylaxis (allogeneic HSCT only), n (%) | |
| CNIs | 34 (81) |
| T cell depletion | 6 (10.7) |
MRD indicates matched related donor; MMRD, mismatched related donor; MUD, matched unrelated donor; MMUD, mismatched unrelated donor.