Table 2.

MODS Diagnosis and Resolution Criteria in Patients with TA-TMA

Organ System	MODS Diagnosis	MODS Resolution
Renal	≥50% reduction of cystC GFR from pre-HSCT value after TA-TMA diagnosis	CystC GFR of 70 mg/mL or a ≥50% increase of cystC GFR from the lowest value during diagnosis of TA-TMA
Pulmonary	Any need for positive-pressure ventilation (noninvasive or invasive) for ≥24 hr with a PaO2/FiO2 ratio <300 or an SpO2/FiO2 ratio <264	Resolution of positive-pressure ventilation (noninvasive or invasive), resolution of oxygen requirements
Cardiovascular	Pulmonary hypertension diagnosed by cardiologist using cardiac catheterization or pulmonary hypertension criteria on echo (right ventricular pressure ≥50% of systemic pressure, ventricular septal flattening, right ventricular dysfunction)	Resolution of pulmonary hypertension (may remain on anti-pulmonary hypertension medications)
Serositis	Clinically significant serositis necessitating medical or surgical therapy	No evidence of clinically serositis requiring medical or surgical therapy
Hypertension (severe)	Hypertension necessitating continuous antihypertensive medication infusion for ≥12 hr	Hypertension control at <99th percentile for age on no more than 2 medications (not including diuretics)
CNS	Neurologic symptoms, mental status changes attributable to the TA-TMA process, or seizures attributable to posterior reversible encephalopathy syndrome	No neurologic symptoms, may remain on antiseizure medications; residual radiologic signs acceptable without clinical symptomatology
GI	GI bleeding and/or intestinal strictures necessitating medical or surgical intervention	No active GI bleeding, no evidence of unresolved intestinal strictures (history of surgical stricture correction is acceptable)