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In vivo efficacy studies in GBM 22 orthotopic [intracranial (IC)] tumors treated with 50 mg/kg TMZ for 5 days with and without 60 mg/kg berzosertib. Kaplan-Meier curves for GBM 22 intracranial xenografts (n = 7–8) show no difference in survival with the addition of berzosertib to TMZ (P = 0.82).
