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Pharmacokinetic profiles of berzosertib in FVB wild-type, Bcrp1−/−, Mdr1a/b−/−, and Mdr1a/b−/− Bcrp1−/− mice after intravenous administration. Plasma concentrations (A), brain concentrations (B), and brain-to-plasma concentration ratios (C) of berzosertib in FVB wild-type, Bcrp1−/−, Mdr1a/b−/−, and Mdr1a/b−/− Bcrp1−/− mice after administration of a single intravenous bolus dose of 20 mg/kg. Data represent mean ± S.D., n = 4.
