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Pharmacokinetics of berzosertib in FVB wild-type and Mdr1a/b−/− Bcrp1−/− mice after intraperitoneal infusion to steady state. (A) Concentrations and (B) organ-to-plasma partition coefficients of berzosertib after an intraperitoneal infusion to steady state at a rate of 10 μg/h in FVB wild-type and Mdr1a/b−/− Bcrp1−/− mice. Data are presented as mean ± S.D., n = 5. **P < 0.01 and ****P < 0.0001.
