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The effect of a pharmacological inhibitor of efflux transport, elacridar, on the plasma and brain concentration of berzosertib. (A) Concentrations in plasma and brain at 2 and 8 hours postdose with and without coadministration of elacridar. (B) Brain-to-plasma ratio at 2 and 8 hours postdose with and without coadministration of elacridar. Data are presented as mean ± S.D., and n = 5 for each group. **P < 0.01 and ***P < 0.005.
