Fig. 8.

Spatial distribution of berzosertib in different regions of the brain after oral administration in mice with GBM 12 intracranial tumors. Data represent mean ± S.D., n = 4–5. *P < 0.05 and **P < 0.01. (A) Representative image of a mouse brain slice marked with tumor core and rim regions. (B) Total concentrations in plasma, normal brain, tumor rim, and tumor core and (C) concentration ratios in brain, tumor rim, and tumor core with respect to plasma after a dose of 20 mg/kg. (D) Total concentrations in plasma, normal brain, tumor rim, and tumor core and (E) concentration ratios in brain, tumor rim, and tumor core with respect to plasma after a dose of 60 mg/kg.