Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Total and free brain partition coefficients summarizing the pharmacokinetic studies of berzosertib in FVB wild-type, Bcrp1−/−, Mdr1a/b−/−, and Mdr1a/b−/− Bcrp1−/− mice
| I.V. | P.O. | Steady State | ||||||
|---|---|---|---|---|---|---|---|---|
| Wild-Type | Bcrp1−/− | Mdr1a/b−/− | Mdr1a/b−/− Bcrp1−/− | Wild-Type | Mdr1a/b −/− Bcrp1−/− | Wild-Type | Mdr1a/b−/− Bcrp1−/− | |
| Kp,brain | 0.64 | 0.84 | 2.36 | 17.13 | 0.70 | 13.9 | 0.8 | 14.0 |
| Kpuu,brain | 0.011 | 0.019 | 0.044 | 0.3426 | 0.012 | 0.278 | 0.014 | 0.28 |
| DAfree | 1 | 1.73 | 4 | 31.15 | 1 | 23.16 | 1 | 20 |
P.O., oral administration
