Table 2.
Summary of effects of the components present in R. graveolens aqueous extract on hepatic cytochrome P450, UGT, and NQO activities in male mice.a
| Treatment | Cyp1a | Cyp2a | Cyp2b | UGT | NQO |
|---|---|---|---|---|---|
| Rue aqueous extract | + | − | + | + | − |
| Rutin | + | − | – | − | − |
| Fmix | − | − | + | − | − |
| Rutin + Fmix | + | − | + | − | − |
Fmix = mixture of furanocoumarins; NQO = NAD(P)H-quinone oxidoreductase; UGT = UDP-glucuronosyltransferase; + = induction; – = unchanged by treatments.
Mice were treated with 0.5 g/kg rue extract for 7 days. Rutin and the mixture of furanocoumarin were administered to mice in a dose according to their respective amount in the mouse dose of rue extract. Cyp1a activities toward 7-ethoxyresorufin and 7-methoxyresorufin were determined. Coumarin and 7-pentoxyresorufin were used as substrates for Cyp2a and Cyp2b, respectively. The UGT and NQO activities were determined using p-nitrophenol and menadione as substrates, respectively.