Table 1.

Different types of polymers and methods applied to prepare insulin-loaded nanoparticles and micelles.

Nanocarriers	Preparation method	Material used	Refs
Nanoparticles	Complex coacervation	Chitosan/sodium alginate	[42]
	Ionic gelation	Chitosan/poly(γ-glutamic acid); Chitosan/alginate	[35,39]
	Solvent evaporation	Poly(ɛ-caprolactone)/Eudragit RS 100; Poly(lactide-co-glycolide)/Eudragit RS100	[14,20]
	Ionotropic gelation and polyelectrolyte complexation	Alginate/dextran sulfate	[38,41]
	Polymerization of monomers	Chitosan/poly(methyl methacrylate); Chitosan/cyclodextrin/polymethacrylic acid	[40,46]
Micelles	Dialysis method	Poly(ethylene glycol)-b-poly(aspartic acid-co-aspartamidophenylboronic acid) and poly(aspartic acid-co-aspartglucosamine), [PEG-b-P(Asp-co-AspPBA) and P(Asp-co-AGA)]	[26]
	Film formation	N-octyl-N-arginine chitosan	[27]

PLGA = poly(lactide-co-glycolide).