Table 1. List of the putative selected genomic regions that have been described in previous studies.
| chr | Start | End | SNPs | genes | OBS | Shared signal with 1KGP_HC | Shared signal with PopHuman Browser (iHS) |
|---|---|---|---|---|---|---|---|
| 1 | 234663636 | 235491532 | 118 | LOC100506795,TOMM20,SNORA14B,RBM34,ARID4B,MIR4753 | Also reported on Karlsson et al. 2013 | xpEHH(0.5%),PBS(0.1%) | GIH,ITU |
| 2 | 72356366 | 73053177 | 20 | CYP26B1,EXOC6B,SNORD78 | Also reported on Liu et al. 2017, Also reported on Karlsson et al. 2013 | xpEHH(0.5%), Tajimas`D(0.5%), PBS(0.5%) | GIH,ITU |
| 2 | 96940073 | 98858761 | 56 | SNRNP200,ITPRIPL1,NCAPH,ARID5A,KANSL3,FER1L5,ANKRD39,SEMA4C,FAM178B,FAHD2B,ANKRD36,ANKRD36B,COX5B,ACTR1B,LOC728537,ZAP70,VWA3B | Also reported on Liu et al. 2017, Also reported on Karlsson et al. 2013 | PBS(0.1%), xpEHH(0.1%) | GIH,ITU |
| 2 | 241662829 | 242033643 | 60 | KIF1A,AGXT,C2orf54,SNED1 | Also reported on Karlsson et al. 2013 | xpEHH(1%) | GIH,ITU |
| 4 | 39289068 | 39529218 | 26 | RFC1,KLB,RPL9,LIAS,LOC401127,UGDH | Also reported on Karlsson et al. 2013 | xpEHH(0.5%) | GIH,ITU |
| 6 | 29550028 | 33086926 | 3545 | SNORD32B,OR2H2,GABBR1,MOG,ZFP57,HLA-F,HLA-F-AS1,IER3,AK098012,DDR1,MIR4640,GTF2H4,VARS2,MUC22,HLA-C,HLA-B,HCP5,PMSP,PRRT1,LOC100507547,PPT2,PPT2-EGFL8,EGFL8,AGPAT1,RNF5,AGER,PBX2,GPSM3,NOTCH4,HLA-DMB,HLA-DMA,BRD2,HLA-DOA,HLA-DPA1,HLA-DPB1,HLA-DPB2 | Also reported on Liu et al. 2017 Also reported on Suo et al. 2012 | PBS(0.5%), xpEHH(1%) | GIH,ITU |
| 7 | 111366163 | 111461829 | 12 | DOCK4,BC043243 | Also reported on Karlsson et al. 2013 | xpEHH(0.5%), PBS(0.5%) | GIH, ITU |
| 7 | 119913721 | 120390387 | 19 | KCND2 | Also reported on Liu et al. 2017, Also reported on Karlsson et al. 2013 | xpEHH(0.5%), Tajimas`D(0.5%), CLR(0.5%) | GIH, ITU |
| 9 | 123714613 | 124095120 | 18 | C5,CNTRL,RAB14,GSN | Also reported on Metspalu et al. 2011, Also reported on Karlsson et al. 2013 | xpEHH(0.5%), PBS(0.1%) | GIH,ITU |
| 10 | 320129 | 735608 | 23 | DIP2C | Also reported on Karlsson et al. 2013 | xpEHH(0.5%), Tajimas`D(1%) | GIH,ITU |
| 10 | 118187423 | 118261387 | 9 | PNLIPRP3,JA611286 | Also reported on Karlsson et al. 2013 | Tajimas`D(0.5%) | |
| 11 | 61447904 | 62622555 | 144 | DAGLA,MYRF,DKFZP434K028,BC020196,TMEM258,MIR611,FEN1,FADS1,MIR1908,FADS2,FADS3,RAB3IL1,BEST1,FTH1,BC132896,SNORD27 | Also reported on Suo et al. 2012 | PBS(0.1%), xpEHH(0.1%) | GIH, ITU |
| 11 | 65479472 | 68846261 | 198 | KAT5,RNASEH2C,AP5B1,SNX32,CFL1,MUS81,EFEMP2,CTSW,FIBP,CCDC85B,FOSL1,KLC2,RAB1B,AK125412,CNIH2,YIF1A,TMEM151A,CD248,RIN1,BRMS1,B3GNT1,SLC29A2,AX747485,NPAS4,MRPL11,LOC100130987,POLD4,CLCF1,RAD9A,PPP1CA,TBC1D10C,CARNS1,RPS6KB2,PTPRCAP,CORO1B,GPR152,CABP4,TMEM134,AIP,PITPNM1,CDK2AP2,CABP2,C11orf24,LRP5,MRGPRF,BC039516,TPCN2 | Also reported on Karlsson et al. 2013 | CLR(0.1%),Tajimas`D(0.5%), xpEHH(0.1%), PBS(0.5%) | GIH, ITU |
| 11 | 126293395 | 132206716 | 884 | KIRREL3,DJ031150,NTM | Also reported on Metspalu et al. 2011 | xpEHH(0.5%), PBS(0.5%) | GIH,ITU |
| 13 | 92050934 | 93519487 | 139 | GPC5 | Also reported on Karlsson et al. 2013 | xpEHH(0.1%), PBS(1%) | GIH,ITU |
| 14 | 63173944 | 63511955 | 35 | KCNH5 | Also reported on Metspalu et al. 2011, Also reported on Karlsson et al. 2013 | xpEHH(0.1%), PBS(0.5%) | GIH,ITU |
| 16 | 29464909 | 32077476 | 122 | BOLA2,KIF22,MAZ,AB209061,AK097472,PRRT2,PAGR1,BC029255,MVP,CDIPT,CDIPT-AS1,SEZ6L2,ASPHD1,KCTD13,TMEM219,TAOK2,HIRIP3,LOC595101,CD2BP2,TBC1D10B,MYLPF,SEPT1,ZNF48,SEPT2,ZNF771,DCTPP1,SEPHS2,ITGAL,MIR4518,ZNF768,ZNF747,AK056973,ZNF764,ZNF688,ZNF785,ZNF689,PRR14,FBRS,LOC730183,SRCAP,SNORA30,LOC100862671,PHKG2,C16orf93,RNF40,ZNF629,BCL7C,MIR4519,BC073928,MIR762,CTF1,FBXL19-AS1,FBXL19,ORAI3,SETD1A,HSD3B7,STX1B,STX4,BC039500,ZNF668,ZNF646,PRSS53,VKORC1,BCKDK,KAT8,PRSS8,PRSS36,FUS,TLS/FUS-ERG,PYCARDC,16orf98,TRIM72,PYDC1,ITGAM,DL489986,ITGAX,IGHV 3–07,IGH | Also reported on Perdomo-Sabogal et al, 2019 for Chinese in Bejing (CHB), Also reported on Karlsson et al. 2013 | Tajimas`D(0.1%), PBS(0.1%), xpEHH(0.1%) | GIH,ITU |
| 16 | 46760587 | 47735434 | 15 | MYLK3,C16orf87,GPT2,ITFG1,PHKB | Also reported on Karlsson et al. 2013 | Tajimas`D(0.5%), PBS(0.5%) | |
| 16 | 87117167 | 87457487 | 57 | AK125749,C16orf95,FBXO31,MAP1LC3B,ZCCHC14 | Also reported on Karlsson et al. 2013 | xpEHH(0.5%), PBS(0.1%) | GIH,ITU |
| 17 | 17876126 | 18011299 | 4 | LRRC48,ATPAF2,BC150162,GID4,DRG2 | Also reported on Karlsson et al. 2013 | PBS(0.5%) | GIH,ITU |
| 17 | 58755212 | 59470192 | 58 | BCAS3 | Also reported on Metspalu et al. 2011, Also reported on Karlsson et al. 2013 | Tajimas’D(0.1%), CLR(0.1%), PBS(1%) | GIH, ITU |
| 20 | 53092265 | 53267710 | 13 | DOK5 | Also reported on Metspalu et al, 2011 | xpEHH(0.5%), Tajimas`D(0.1%), CLR(0.1%), PBS(0.1%) | |
| 22 | 35462129 | 35483380 | 3 | ISX | Also reported on Metspalu et al, 2011 | ||
| 22 | 46756730 | 46933067 | 49 | CELSR1 | Also reported on Metspalu et al, 2011, Also reported on Karlsson et al. 2013 | xpEHH(0.5%), Tajimas`D(0.5%) |
List of the regions with putative signatures of natural selection in our study that have been described in other studies, with a particular emphasis in studies in South Asian populations or other Asian groups. 1: Metspalu et al. 2011, 2: Suo et al. 2012, 3: Karlsson et al. 2013, 4: Liu et al. 2017, 5: Perdomo-Sabogal and Nowick, 2019. In Blue, we show regions with results in the 0.5% of the most significant values for at least one method, and in red the results in the top 0.1% most significant results for at least one method. We also highlight the regions that also have significant results in the 1kgp high coverage data (1kgp_HC), and in the PopHuman Browser with iHS.