Table 2. Biochemical pathway analysis of HBV induced changes in cholesterol and lipid metabolites.
| Pathway | Biochemical Name | HBV/ No HBV (fold change) | p-value (non-adjusted) |
|---|---|---|---|
| Mevalonate Metabolism | 3-hydroxy-3-methylglutarate | 1.56 | 0.018 |
| Sterol | cholesterol | 0.99 | 0.924 |
| cholesterol sulfate | 0.91 | 0.268 | |
| 4-cholesten-3-one | 1.07 | 0.591 | |
| campesterol | 0.81 | 0.598 | |
| 7-hydroxycholesterol (alpha or beta) | 0.87 | 0.357 | |
| Phosphatidylserine (PS) | 1-palmitoyl-2-arachidonoyl-GPS (16:0/20:4) | 0.93 | 0.635 |
| 1-stearoyl-2-oleoyl-GPS (18:0/18:1) | 0.77 | 0.019 | |
| 1-stearoyl-2-linoleoyl-GPS (18:0/18:2) | 0.81 | 0.018 | |
| 1-stearoyl-2-arachidonoyl-GPS (18:0/20:4) | 0.93 | 0.520 | |
| Sphingolipid Synthesis | sphinganine | 1.18 | 0.062 |
| sphingadienine | 1.21 | 0.186 | |
| phytosphingosine | 1.10 | 0.265 | |
| Sphingosines | sphingosine | 1.18 | 0.041 |
| sphingosine 1-phosphate | 0.96 | 0.884 | |
| hexadecasphingosine (d16:1)* | 1.22 | 0.022 | |
| heptadecasphingosine (d17:1) | 1.14 | 0.274 | |
| Glycosyl PE | 1-palmitoyl-2-arachidonoyl-glycosyl-GPE (16:0/20:4)** | 2.00 | 0.120 |
| 1-palmitoyl-2-docosahexaenoyl-glycosyl-GPE (16:0/22:6)** | 1.96 | 0.292 | |
| 1-stearoyl-2-linoleoyl-glycosyl-GPE (18:0/18:2)** | 1.88 | 0.087 | |
| 1-stearoyl-2-arachidonoyl-glycosyl-GPE (18:0/20:4)** | 1.78 | 0.147 | |
| 1-stearoyl-2-docosahexaenoyl-glycosyl-GPE (18:0/22:6)** | 2.25 | 0.091 |
* Indicates a compound that has not been confirmed based on a standard
** indicates a compound for which a standard is not available. Metabolites were identified by virtue of their recurrent nature (both chromatographic and mass spectral).