Table 4. – Evaluation of predictive models for cardiac adverse events**.
| C-statistics (95% CI)* | NRI (95% CI) | IDI (95% CI) | |
|---|---|---|---|
| Cardiac death | |||
| Traditional risk factors | 0.704(0.633-0.776) | Ref | Ref |
| Traditional risk factors +SII | 0.780(0.713-0.847) | 0.4962(0.2661.0.7264) | 0.0857(0.058.0.1133) |
| p value | 0.02 | 0.0002 | <0.0001 |
| Nonfatal myocardial infarction | |||
| Traditional risk factors | 0.641(0.571-0.710) | Ref | Ref |
| Traditional risk factors +SII | 0.757(0.688-0.826) | 0.4936(0.2772.0.7101) | 0.0743(0.054.0.0946) |
| p value | 0.0006 | <0.0001 | <0.0001 |
| Nonfatal stroke | |||
| Traditional risk factors | 0.615(0.481-0.750) | Ref | Ref |
| Traditional risk factors +SII | 0.756(0.631-0.881) | 0.4655(0.0871.0.844) | 0.0307(0.0158.0.0457) |
| p value | 0.043 | 0.031 | <0.0001 |
| Hospitalization for CHF | |||
| Traditional risk factors | 0.884(0.852-0.914) | Ref | Ref |
| Traditional risk factors +SII | 0.939(0.918-0.961) | 0.7183(0.5413.0.8953) | 0.1448(0.1031.0.1865) |
| p value | <0.0001 | <0.0001 | <0.0001 |
| Revascularization (PCI or CABG) | |||
| Traditional risk factors | 0.923(0.904-0.942) | Ref | Ref |
| Traditional risk factors +SII | 0.931(0.915-0.949) | 0.2971(0.1254.0.4687) | 0.0231(0.0089.0.0371) |
| p value | 0.036 | 0.0009 | 0.0014 |
| MACE | |||
| Traditional risk factors | 0.644(0.592-0.696) | Ref | Ref |
| Traditional risk factors +SII | 0.754(0.703-0.804) | 0.4539(0.2806.0.6271) | 0.1073(0.0834.0.1311) |
| p value | <0.0001 | <0.0001 | <0.0001 |
NRI: net reclassification improvement, IDI: integrated discrimination improvement, SII: systemic immune-inflammation index, CHF: congestive heart failure, PCI: percutaneous coronary intervention, CABG: coronary artery by-pass graft, MACE: major adverse cardiovascular events. * p values for c-statistics: DeLong test. ** Traditional risk factors: age, hypertension, diabetes mellitus, and male gender.