Figure 2.

Highly expanded T- and B-cell clonotypes in the eye. Robust clonal expansion is seen in a single ocular T- or B-cell lineage, with ocular CD8 T-cell clonotypes more abundant in the blood compared with CD4 T-cell clonotypes. A, Bar graph showing T- and B-cell diversity and clonality in blood and ocular T or B cells for each indicated patient, as measured by the Gini coefficient, where on a scale from 0 to 1, 0 indicates that all sequences have the same frequency and 1 indicates that the repertoire is dominated by a single sequence. B, Pie charts showing the proportions of the 5 most frequent ocular CD4 T-cell, CD8 T-cell, or B-cell clonotypes for each individual. C, Graph showing composite frequency of the top 5 CD4 and CD8 T-cell clonotypes from (B) in both the eye and blood for each patient. D, Graphs showing percent overlap of all CD4 and CD8 T-cell clonotypes in the blood and eye from all patients. Percentage is calculated as the number of shared individual clonotypes in each row-column intersection divided by the total number of clonotypes in each column without regard to clonotype frequency. Overlap is detected only between blood and eye samples within a single patient, and not between patients.