Table 1. Literature Data Set Profile.

			ΔΔG‡ [kcal mol–1]
literature ID	number of reactions	putative reaction mechanism	average	minimum	maximum
028	20	Mannicha	0.92	0	1.51
129	24	Mannicha	1.03	0.11	1.53
230	14	Mannicha	0.68	0	1.23
331	13	Additionb	1.65	0.06	3.13
432	8	Mannicha	0.22	0.06	0.75
533	13	Friedel–Craftsc	1.73	1.22	1.98
634	24	Additionb	1.51	0	3.13

^aDirect aza-Mannich reaction.

^bCatalytic asymmetric addition of an amide (imide) by nucleophilic attack.

^cFriedel–Crafts reaction.