Scheme 1. Preparation of (a) Sulfo-Cyanine5 Maleimide Conjugate of N-(7-Acetamido-3-methyl-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoliean-9-yl)-3-mercaptopropanamide (2), (b) N-(7-Acetamido-3-methyl-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl)-3-((2-amino-2-oxoethyl)thio)propanamide (5), and (c) Chemical Structure of MorHap-Cy5.
