Table 6. PXR Activation by Compounds from Glycyrrhiza Species.
| fold increase in PXR activity at |
||||
|---|---|---|---|---|
| code | compound name | 30 μM ± SD | 10 μM ± SD | 3 μM ± SD |
| GG-14 | (3R)-glabridin | 6.53 ± 0.38 | 3.29 ± 0.09 | 1.99 ± 0.30 |
| GU-128 | licoisoflavone A | 3.88 ± 0.41 | 2.53 ± 0.17 | 1.87 ± 0.19 |
| GG-98 | liquiritin | 1.28 ± 0.07 | 1.07 ± 0.22 | 0.82 ± 0.15 |
| GU-03 | glycycoumarin | 2.46 ± 0.22 | 1.44 ± 0.05 | 1.19 ± 0.14 |
| GI-19 | isoliquiritigenina | 1.34 ± 0.03 | 1.20 ± 0.16 | 0.90 ± 0.02 |
| GU-130 | licoisoflavanone | 3.29 ± 0.31 | 2.40 ± 0.31 | 1.90 ± 0.31 |
| positive control | rifampicin | 3.51 ± 0.42 | 3.20 ± 0.80 | 2.70 ± 0.50 |
a
Close mimic for neoisoliquiritigenin (GG-103).