Fig. 3.
Time course analysis in fluorescence reflectance imaging (FRI) (a) Representative horizontal map of an NTL (upper row) and an arcAβ mouse (lower row) preinjection to 120 minutes after CRANAD-2 injection; (b) Spectra detected in the brains of arcAβ mice after injection; (c) White-light (left) and NIRF (right) images of one arcAβ mouse head with epilated skin over the head. Region of interest = 41 cm2; (d) Time course of NIRF signal in the brain of arcAβ and age-matched non-transgenic littermates; (e) Area under curve (AUC) of the cortical regions of arcAβ (n = 4) and NTL (n = 4) mice.