Table 2.

Characteristics of available vaccines against Monkeypox.

Vaccine name	JYNNEOS (Imvamune or Imvanex)	ACAM2000.
Type	Replication-deficient Live virus vaccine	Live cowpox Vaccinia virus vaccine
Doses	2 doses, 28 days apart	1 dose
Immune Response	2 weeks after the second dose	4 weeks post-vaccination
Major Side Effects	injection site reactions, Muscle pain, Headache, Fatigue.	Injection site wound (Take) may require 6 weeks to heal, inadvertent inoculation with vaccinia, Myopericarditis.
Pregnancy	Not contraindicated in pregnancy and breastfeeding based on animal studies.	Contraindicated in Pregnancy.
Contraindication	Severe Allergy to components (gentamicin, ciprofloxacin, egg protein)	Cardiac disease, Congenital or acquired immune deficiency disorders, e.g. HIV, skin conditions like atopic dermatitis/eczema; Eye disorder treated with topical steroids
Availability	Limited	Ample