Figure 3.

SOMCL-19-133 displays broad-spectrum inhibitory effects on the viability of a panel of human cancer cell lines. (a) Dose-response curves of SOMCL-19-133 and MLN4924-treated HCT-116 and RKO cells. Data are presented as mean ± SEM, n = 3. (b) Colony-forming efficiency of HCT-116, RKO, HuTu80, and HT-29 cells treated with SOMCL-19-133, MLN4924, or Control for 11 days. Data are mean ± SEM, n = 3. (c) IC₅₀ values of SOMCL-19-133 and MLN4924 against a panel of human tumor cell lines were assessed by using SRB or CCK8 assay. A panel of 28 human cancer cell lines was treated with SOMCL-19-133 or MLN4924 at a series of different concentrations (0.001-20 µM), and the viable cells are measured after 72 h of treatment. Data were presented as mean ± SEM, n = 3.