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Oral administration of SOMCL-19-133 suppresses the growth of RKO and MV-4-11 xenografts in nude mice. (a and b) The effects of oral administration of SOMCL-19-133 on (a) human colon cancer RKO and (b) human leukemia MV-4-11 xenografts. Mice bearing subcutaneous xenografts were dosed with SOMCL-19-133 orally daily, or MLN4924 (120 mg/kg; i.v.) twice a week for (a) 21 days or (b) 18 days (n = 6). The tail indicated the tumor disappeared in that mouse.
