Table 2.
Calculation of the CoLab linear predictor
| Variable | β | Exclusion limit | Relative importance (%) |
| Intercept | −6.885 | – | |
| Erythrocytes (/pL) | 0.9379 | Erythrocytes <2.9/pL | 52 |
| Leucocytes (/nL) | −0.1298 | 46 | |
| Eosinophils (/nL) | −6.834 | 86 | |
| Basophils (/nL) | −47.70 | Basophils >0.33/nL | 100 |
| Log10 of bilirubin (µmol/L) | −1.142 | Bilirubin >169 µmol/L | 26 |
| Log10 of LD (U/L) | 5.369 | LD >1564 U/L | 58 |
| Log10 of ALP (IU/L) | −3.114 | AF >1000 IU/L | 45 |
| Log10 of gGT (U/L) | 0.3605 | gGT >1611 U/L | 11 |
| Albumin (g/L) | −0.1156 | 45 | |
| CRP (mg/L) | 0.002560 | 15 | |
| Age (years) | 0.002275 | 4 |
The CoLab linear predictor (LP) is calculated by summing the intercept and the products of the 11 variables with their corresponding coefficients (βs). CoLab LP=−6.885+[erythrocytes]×0.9379−[leucocytes]×0.1298−[eosinophils]×6.834−[basophils]×47.7−log10[bilirubin]×1.142+log10[LD]×5.369−log10[ALP]×3.114+log10[gGT]×0.3605−[albumin]×0.1156+[CRP]×0.02560+[age]×0.002275. The LP can be converted into a CoLab-score (see figure 2) or into a probability if the prevalence is known or estimated (see details in online supplemental material 1). The CoLab-score is not valid if any of the variables exceeds the limits in the third column. The relative importance ranks the importance of variables in predicting the outcome, relative to the most important variable (in this case basophils).
ALP, alkaline phosphatase; CRP, C reactive protein; gGT, gamma-glutamyltransferase; LD, lactate dehydrogenase.