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. 2022 Jul 6;608(7921):98–107. doi: 10.1038/s41586-022-04922-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, A monophyletic lineage tree of the 3,257 cells with all 13 TargetBC Tape arrays recovered. The UPGMA clustering method was used to construct the tree from a distance matrix that takes into account the order of edits within the TAPE-1 arrays, by discounting matches for which earlier sites along the same DNA Tape were not also identically edited. b, A lineage tree constructed by order-aware UPGMA for a subset of 32 cells drawn from the larger tree, specifically the two 16-cell clades marked with light blue in the circular tree. Numbers next to branching points denote bootstrap values out of 100 resamplings. The 59 sites of the 13 TargetBC-associated Tape arrays are represented to the right, with InsertBCs coloured by edit identity. Cells are identified by the 16-bp CellBCs (10x Chromium v3 chemistry) listed on the far right. A higher-resolution version of the entire tree of 3,257 cells in the same format is provided in Supplementary Fig. 1.