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. 2022 Jul 27;608(7921):192–198. doi: 10.1038/s41586-022-04984-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, Fractional abundance (M+4/total) of labelled metabolites in main Fig. 3c. Replicate samples (○). Mean (bars). SEM (error bars); n = 3 biological replicates. *significant difference from treatment marked (†), two-tailed student’s t-test, (p<alpha 0.05). b, Fractional abundance (M+4/total) of labelled metabolites in main Fig. 3d. Replicate samples (○). Mean (bars). SEM (error bars); n = 3 biological replicates. *significant difference from treatment marked (†), two-tailed student’s t-test, (p<alpha 0.05). c, Two-dimensional proliferation assay with PANK4 KO AKT+/+ MCF10A cells stably expressing empty vector or PANK4 (WT, T406A, or T406E) in serum-free media with serum replacement and growth factors over 4 days. Replicate samples (○). SEM (error bars); n = 3 biological replicates. *significant difference from treatment marked (†), one-way ANOVA with Tukey’s test, (p<alpha 0.05). Significance based on day 4 values. Representative of two independent experiments.