Table 1.
Demographic and clinical characteristics of the population of cirrhotic patients included in the analysis, stratified according to the presence of portal vein thrombosis (PVT), venous thromboembolism (VTE) or no thrombosis (NT)
| Overall population (N = 7445) | PVT group (N = 382) | VTE group (N = 95) | NT group (N = 6968) |
p value PVT vs NT |
p value VTE vs NT |
p value PVT vs VTE |
|
|---|---|---|---|---|---|---|---|
| Gender | |||||||
| Male | 5143 (69.08) | 276 (72.25) | 59 (62.11) | 4808 (69.00) | 0.19 | 0.15 | 0.06 |
| Female | 2302 (30.92) | 106 (27.75) | 36 (37.89) | 2160 (31.00) | |||
| Age (years) | 64 (54.00–72.00) | 64 (55.20–71.70) | 67 (59.50–76.00) | 63 (54.00–72.00) | 0.44 | 0.006 | 0.034 |
| Any liver cirrhosis complicationa | 3006 (40.37) | 172 (45.02) | 31 (32.63) | 2803 (40.22) | 0.07 | 0.14 | 0.03 |
| Ascites | 1008 (13.53) | 71 (18.58) | 13 (13.68) | 924 (13.26) | 0.004 | 0.87 | 0.29 |
| Endoscopic signs of portal hypertension | 1246 (16.73) | 102 (26.70) | 12 (12.63) | 1132 (16.24) | < 0.0001 | 0.40 | 0.003 |
| HE | 591 (7.93) | 159 (41.62) | 14 (14.73) | 418 (5.99) | < 0.0001 | 0.002 | < 0.0001 |
| SBP | 19 (0.25) | – | 0 (0.00) | 19 (0.27) | 0.62 | 1 | 1 |
| HRS | 84 (1.12) | – | 1 (1.05) | 83 (1.19) | 0.02 | 1 | 0.19 |
| Variceal bleeding | 396 (5.31) | 8 (2.09) | – | 388 (5.56) | 0.0015 | 0.0100 | 0.37 |
| Any tumor | 2036 (27.34) | 178 (46.59) | 40 (42.10) | 1818 (26.09) | < 0.0001 | 0.0008 | 0.49 |
| HCC | 1524 (20.47) | 162 (42.40) | 26 (27.36) | 1336 (19.17) | 0.0001 | 0.049 | 0.007 |
| Other tumors | 596 (8.00) | 18 (4.71) | 16 (16.84) | 562 (8.06) | 0.01 | 0.007 | 0.0001 |
| Diabetes | 1047 (14.06) | 80 (20.94) | 15 (15.78) | 952 (13.66) | 0.0001 | 0.55 | 0.31 |
| Cardiac or respiratory insufficiency | 384 (5.15) | 14 (3.66) | 12 (12.63) | 358 (5.13) | 0.23 | 0.004 | 0.002 |
| AMI or stroke | 22 (0.29) | 1 (0.26) | 2 (2.10) | 19 (0.27) | 1 | 0.03 | 0.10 |
| Acute infection | 655 (8.79) | 30 (7.85) | 21 (22.10) | 603 (8.65) | 0.64 | < 0.0001 | 0.0002 |
| Potentially on anticoagulant treatmentb | 166 (2.22) | 3 (0.78) | 0 (0.00) | 163 (2.33) | 0.049 | 0.17 | 1 |
| Abdominal surgery/invasive procedures | 1079 (14.49) | 101 (26.43) | 19 (20.00) | 961 (13.79) | < 0.0001 | 0.09 | 0.23 |
Continuous variables reported as median and interquartile range, categorical ones as frequencies and percentages. Statistically significant comparisons are highlighted in bold.
HE hepatic encephalopathy, SBP spontaneous bacterial peritonitis, HRS hepatorenal syndrome, HCC hepatocellular carcinoma, AMI acute myocardial infarction
aExcluding HCC and PVT
bAtrial flutter/fibrillation, valvulopathies, previous VTE events