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. 2022 Jun 24;96(10):2815–2824. doi: 10.1007/s00204-022-03327-w

Table 5.

Benchmark doses (BMDs) for 10% benchmark responses (BMRs) with 95% Confidence Intervals (BMDL– BMDH) (μM) calculated on data obtained by different method on late morphogenesis exposed group (sensible subgroup)

Exposure window BMD BMDL BMDH
Gross morphological evaluation 17.34 9.69 inf
Deglutition test 5.52 2.92 6.89
Cartilage full evaluation 4.12 3.29 5.08
Cartilage whole mount evaluation 31.83 19.1 inf
M–PQ angle 21.7 17.5 22.5