Table 3.

Descriptive statistics and differential analysis of the ABAS-II adaptive skills and domains in PMS population (n=51)

ABAS-II	Total sample (n=51)	SHANK3deletion (n=45)	SHANK3mutation (n=6)	Independent sample tests
				Student’s t-test	U-Mann-Whitney
				p valuea	p valueb
General Adaptive Composite median (IQR)	53.0 (51–53)**	54.5 (51–74)*	58.1 (51–80)**	---	0.78
Conceptual domain, median (IQR)	54.0 (53–54)**	55.1 (53–85)**	58.8 (53–78)**	---	0.16
Communication, median (IQR)	1.0 (1–1)*	1.2 (1–8)*	2.2 (1–7)*	---	0.26
Functional academics, median (IQR)	1.0 (1–1)*	1.2 (1–9)*	1.0 (1–1)*	---	0.94
Self-direction, mean (SD)	2.1 (2.5)*	1.9 (2.4)*	3.2 (3.7)*	0.28	---
Social, median (IQR)	53.0 (53–54)**	56.18 (51–94)**	67.7 (51–110)**	---	0.43
Leisure skills, mean (SD)	2.1 (2.6)*	2.0 (2.3)*	3.8 (5.2)*	0.43	---
Social interaction skills, mean (SD)	1.7 (2.2)*	1.6 (1.9)*	4.3 (4.6)*	0.21	---
Practical, median (IQR)	56.0 (52–56)**	56.9 (51–75)**	56.0 (51–69)**	---	0.58
Community use, mean (SD)	1.3 (0.9)*	1.5 (2.1)*	1.7 (1.2)*	0.90	---
Home or school living, median (IQR)	1.0 (1–5)*	2.9 (1–13)*	4.5 (1–12)*	---	0.41
Health and safety, mean (SD)	1.6 (1.5)*	1.67 (1.6)*	1.3 (0.81)*	0.62	---
Self-care, mean (SD)	1.4 (1.4)*	1.4 (1.5)*	1.2 (0.4)*	0.65	---
Motor/work, median (IQR)	1.0 (1–1)*	1.0 (1–1)*	1.0 (1–1)*	---	1.00

IQR interquartile range, SD standard deviation

^aStudent’s t-test (between-group differences if p<0.05)

^bU-Mann-Whitney test (between-group differences if p<0.05)

^*Atypical on ABAS-II adaptive skills subscales is ≤ 7

^**Atypical on ABAS-II GAC/conceptual/social/practical scores is ≤ 85

No missing data was reported