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Convergent KEs and divergent KEs in the HFRT-AOP network
| Convergent KEs | Divergent KEs | ||
|---|---|---|---|
| KE type | KE name | KE type | KE name |
| AO | Impaired fertility | KE | Reduced E2 in circulation |
| AO | Irregularities, ovarian cycle | KE | Altered transcription of genes by AR |
| KE | Decreased all-trans retinoic acid (atRA) concentration | KE | Increased NR2F1 activation |
| KE | Accelerated follicle formation | ||
| KE | Impaired oocyte maturation | ||
