Table 2.
Initial activity screening results. +, detected; −, not detected; n.a., not applicable
| Substrate | Hydrolysis of carboxamide linker | Hydrolysis of carboxamide/ester in head group | ||||
|---|---|---|---|---|---|---|
| hCES1b | hCES1c | hCES2 | hCES1b | hCES1c | hCES2 | |
| 3,5-AB-5F-FUPPYCA | − | − | − | − | − | − |
| AB-5F-P7AICA | − | − | − | − | − | − |
| A-CHMINACA | − | − | − | n.a | n.a | n.a |
| DMBA-CHMINACA | − | − | − | n.a | n.a | n.a |
| MBA-CHMINACA | − | − | − | n.a | n.a | n.a |
| MDMB-4F-BINACA | − | − | − | + | + | - |
| MDMB-4en-PINACA | − | − | − | + | + | - |
| MDMB-FUBICA | − | − | − | − | + | - |
| MDMB-5F-PICA | − | − | − | − | − | - |
| MMB-CHMICA | − | − | − | + | + | - |
| MMB-4en-PICA | − | − | − | + | + | + |
| MMB-FUBINACA | − | − | − | + | + | + |
| MPhP-5F-PICA | − | − | − | + | + | + |