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. 2022 Aug 4;13:4471. doi: 10.1038/s41467-022-31907-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a 3D reconstruction of HiSiaQM in complex with Mb3 in lipid nanodiscs (contour level 0.384). A map of the nanodisc was overlayed in transparent grey to show the relative position of the lipid bilayer. Selected secondary structure elements are indicated. The individual domains and their color code are identified in panel (b). b Topology diagram of HiSiaQM. c Cartoon representation of HiSiaQM with the same color scheme as in (a) and (b). Secondary structure elements are indicated.