Skip to main content
. 2022 Aug 4;13:4471. doi: 10.1038/s41467-022-31907-y

Fig. 2. Comparison of the TRAP transporter HiSiaQM with elevator-type transporters.

Fig. 2

a Superposition of HiSiaQM (colored coded as in Fig. 1) onto one unit of the dimeric VcINDY transporter in its Ci state (magenta, 5UL939). The outline of the two VcINDY monomers is drawn as a black line. Note that the Q-domain of HiSiaQM clearly crosses the “border” between the two VcINDY monomers. b Close-up view of the Q1–Q4 helices from (a). The magenta helices are part of the VcINDY stator domain. c The substrate-binding site of VcINDY aligned to HiSiaQM, showing the two Na+ ions and the citrate molecule in the VcINDY structure. d Side view of HiSiaQM in the Ci state from Fig. 1c (left) and a model of the outward open Co state (right) that was constructed based on the Co state of VcINDY31,45–47.