Table 3.
The role of exosomal circRNAs in the pathogenesis of OA
| circRNAs | Sample | Exosome source | Role | Reference |
|---|---|---|---|---|
| circ-BRWD1 | Human | Chondrocyte cell line CHON-001 treated with IL-1β | Promotes OA progression by regulating the miR-1277/TRAF6 axis | 73 |
| circHIPK3 | Human | MSCs | Promotes chondrocyte proliferation and migration and suppresses apoptosis via the miR-124-3p/MYH9 axis | 74 |
| circ_0001846 | Human | Chondrocyte cell line CHON-001 treated with IL-1β | Modulates IL-1β-induced chondrocyte damage by miR-149-5p/WNT5B axis | 99 |
| circRNA_0001236 | Human | MSCs | Alleviates cartilage degradation through the miR3677-3p/Sox9 axis | 177 |
| circRNA3503 | Human | CircRNA3503-overexpressed synovium MSCs | Alleviates chondrocyte apoptosis and ECM imbalance by acting as sponges of miR181c-3p and let-7b-3p | 178 |
OA osteoarthritis, MSCs mesenchymal stem cells, IL-1β interleukin-1β, TRAF6 TNF receptor-associated factor 6, MYH9 myosin heavy chain 9, SOX9 SRY-box transcription factor 9, ECM extracellular matrix, WNT5B wingless-type MMTV integration site family member 5B