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. 2022 Aug 4;8:351. doi: 10.1038/s41420-022-01145-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A The mRNA levels of CDK3in ccRCC cells. B The mRNA levels of CDK3 in 12 pairs of ccRCC tissues and neighboring normal tissues. C, D CDK3 protein and mRNA expression after overexpression or knockdown. E Cell growth curves of CCK8 assays for indicated cells. F, G Migration and invasion assay for overexpressing or knockdown CDK3 (Magnification: 200×). t-test, *p < 0.05, **p < 0.01,***p < 0.001, ****p < 0.0001. H The expression change of EMT markers in overexpressing CDK3 cells or siCDK3 cells.