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. 2022 Aug 4;12:13396. doi: 10.1038/s41598-022-16968-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Study cohort overview of routine data and additional plasma marker. (A) Schematic overview of available data. (B) Pairwise-associations tests of routinely available preoperative data with four outcome parameters. Colors and size of the circle indicate the strength of association. The first nine columns correspond to general clinical information and known risk factors. The last 11 columns represent routine blood markers measured one day before surgery. The risk of mortality was significantly associated with the level of preoperative total bilirubin after adjusting for multiple testing (Kruskal–Wallis test unadjusted p value of 0.0033, FDR adj. p = 0.084).