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. 2022 Aug 4;12:13384. doi: 10.1038/s41598-022-16449-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of Cl-amidine on neutrophil extracellular trap (NET) formation during the contact hypersensitivity response in wild-type mice (WT) and Il36rn^−/− mice (KO). (a) Representative immunofluorescence image of NET structures. Arrow heads show the formation NETs that were myeloperoxidase-positive (red) and citrullinated histone-positive (green). The nuclei were counterstained with 4’,6-diamidino-2-phenylindole (DAPI; blue). Scale bar = 50 μm. (b) The area of NETs was measured using the ImageJ software. Each histogram shows the relative area of NETs at 48 h after the DNFB challenge. All values represent the mean ± SEM obtained from six mice per group (**p < 0.01).