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. 2022 Aug 4;12:13407. doi: 10.1038/s41598-022-17319-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between CT and MRsimCT values. MRsimCT values prior to HU_bone scaling in (2) span a range from 0 to 1 and can be used as an estimate for bone fraction. For the CT parameters used in this study, pure bone was calculated to have a value of 2000 HU³⁶. The black line depicts the nominal relationship between CT and MRsimCT values. Because only three ex vivo skulls were used in this study, using a linear regression to predict CT HU from MRsimCT values may overfit to the data. Therefore, the nominal linear relationship was used to predict CT HU instead.