Table 2.

Age-standardized incidence-based mortality rates (ASMR) and 95% CIs of hepatocellular carcinoma overall and by sex, race /ethnicity and age in the U.S., SEER-13 Registries, 1992-2018

	1992			2018			Joinpoints		APC (%) Trends			AAPC
	Deaths	ASMR	95% CI	Deaths	ASMR	95% CI	1	2	1	2	3	%	95% CI
	542	1.74	(1.60, 1.90)	2,889	5.39	(5.20, 5.60)	1994	2013	29.0*	3.4*	−2.2*	4.1*	(3.2, 5.0)
Sex
Men	396	2.92	(2.63, 3.22)	2,224	9.02	(8.64, 9.42)	1994	2012	26.9*	3.6*	−1.3*	4.1*	(3.1, 5.1)
Women	146	0.82	(0.70, 0.97)	665	2.33	(2.16, 2.52)	1995	2014	20.6*	2.6*	−2.7	3.7*	(2.3, 5.0)
Race/ethnicity
Non-Hispanic White	252	1.06	(0.93, 1.20)	1,272	3.80	(3.59, 4.03)	1994	2014	28.0*	3.9*	−2.5	4.5*	(3.0, 6.1)
Non-Hispanic Black	69	2.68	(2.07, 3.39)	417	8.25	(7.45, 9.11)	2010	–	4.8*	−0.8	–	3.1*	(2.1, 4.1)
Hispanic	77	3.01	(2.35, 3.79)	595	8.07	(7.40, 8.77)	1996	2013	14.1*	2.9*	−2.5	3.4*	(1.7, 5.2)
Asian/Pacific Islander	141	6.09	(5.09, 7.22)	532	7.32	(6.71, 7.98)	1994	2012	24.3*	−0.2	−4.5*	0.4	(−1.1, 2.0)
American Indian/Alaska Native	--	1.39	(0.23, 4.14)	65	13.09	(9.99, 16.83)	–	–	4.8*	–	–	4.8*	(3.4, 6.2)
Age at diagnosis, yrs
<50	59	0.24	(0.18, 0.31)	61	0.22	(0.16, 0.28)	1999	2010	9.8*	−2.2*	−9.6*	−1.5	(−3.1, 0.1)
50-69	241	4.07	(3.57, 4.62)	1,585	13.99	(13.30, 14.70)	1994	2013	26.3*	4.5*	−3.1*	4.5*	(3.3, 5.8)
70-84	214	9.29	(8.08, 10.63)	1,005	29.11	(27.33, 30.98)	1994	2013	26.9*	3.1*	−0.3	4.1*	(2.9, 5.4)

Abbreviations: 95%CI, 95% Confidence Interval; APC, annual percent change; AAPC, average annual percent change

Asterisk denotes that the trend was statistically different from zero at alpha=0.05

Cases may not add up to total due to unknown race/ethnicity categories (data not shown)